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Phentermine

Phentermine may be appropriate for carefully selected patients who are at significant medical risk because of their obesity. Phentermine is not recommended for use by people who are only mildly overweight unless they have health problems that are made worse by their weight. Phentermine should not be used only to improve appearance. For most severely obese people, achieving an "ideal body weight" is both unrealistic and unnecessary to improve their health and reduce their risk for disease. Most patients should not expect to reach an ideal body weight using the currently available medications. A modest weight loss of 5 to 10 percent of the patient’s starting body weight can improve their health and reduce their risk factors for disease. Use of Phentermine for cosmetic purposes is not appropriate.

Agitation Allergy/Hypersensitivity to other sympathomimetic amines Atherosclerosis Cardiovascular disease Glaucoma High blood pressure Hyperthyroidism Previous history of drug abuse and others*

Obesity is a chronic disease that affects many people and often requires medical treatment to promote and sustain weight loss. Phentermine, a prescription medication, can be used to assist with the battle of obesity. While most side effects of Phentermine are mild, serious complications involving Phentermine have been reported. Phentermine should only be used by patients who are at increased medical risk because of their obesity. Phentermine should not be used for "cosmetic" weight loss.

Phentermine is a tablet that is used in the short-term management of obesity. It comes in various colours, in tablet or capsule form and in strengths of 15, 30 and 37.5 milligram.

Phentermine works by suppressing appetite via a central mechanism in the brain. Use of Phentermine in combination with other appetite suppressant medicine is generally not recommended.

Phentermine is an effective form of therapy for obese patients who need to lose weight to decrease diseases associated with obesity. The magnitude of the weight loss through using Phentermine will depend on the degree of caloric restriction and the use of a graded exercise program.

Phentermine should be used as a short term drug to help patients to start losing weight while the patient is undergoing permanent long term changes in their attitude towards food and exercise. The body starts to build up a resistance to the effects of Phentermine after a few weeks of treatment, by which time the patient should be well on their way to a new lifestyle and ready to stop taking Phentermine while continuing to maintain a healthy weight on their own.

Adipex-P Fastin Ionamin Obenix Obephen Oby-Cap Oby-Trim Panshape M Phentercot Phentride Pro-Fast (HS,SA,SR) Teramine Zantryl

Taking Phentermine is not a substitute for proper diet. For maximum effect, Phentermine must be used in conjunction with a diet and exercise program.

Phentermine is the generic name of the drug. It is distributed under different brand names including ADIPEX-P and IONAMIN. There are many popular brand names of Phentermine. In terms of fighting obesity, they are all considered clinically equivalent in producing weight loss. Phentermine comes in immediate release or time-release formulas. Immediate release Phentermine pills enter the blood stream as soon as they are taken and time-release Phentermine capsules release their medication into the body over an extended period of time, generally 8 or 12 hours.

Phentermine is a phenethylamine primary used as an appetite suppressant. It is typically prescribed for individuals who are at increased medical risk because of their weight, as opposed to cosmetic weight loss.

Phentermine is sold either as an immediate-release formulation (Adipex®) or as a slow-release resin (Ionamin®, Duromine® in Australia and New Zealand).

Phentermine is still available by itself in most countries, including the U.S. However, because it is similar to the amphetamines, individuals may develop an addiction to it. Hence, it is classified as a controlled substance in many countries. Internationally, phentermine is a schedule IV drug under the Convention on Psychotropic Substances (PDF file). In the United States, it is classified as a Schedule IV controlled substance under the Controlled Substances Act.

Mechanism of action

Phentermine, as many other prescription drugs, works with neurotransmitters in the brain. It is a centrally-acting stimulant chemically related to the amphetamines. It stimulates neuron bundles to release a particular group of neurotransmitters known as catecholamines; these include dopamine, epinephrine (also known as adrenalin), and norepinephrine (noradrenaline). This is the same mechanism of action as other stimulant appetite suppresants such as sibutramine, diethylpropion, and dextroamphetamine.

The neurotransmitters signal a fight-or-flight response in the body which, in turn, puts a halt to the hunger signal. As a result, it causes a loss in appetite because the brain does not receive the hunger message.

Clinical use

Generally, it is recommended by the FDA that phentermine should be used short-term (usually interpreted as 'up to 12 weeks'), while following nonpharmacological approaches to weight loss such as healthy dieting and exercise. However, recommendations limiting its use for short-term treatment may be controversial. One reason given behind limiting its use to 12 weeks is drug tolerance, whereby phentermine loses its appetite-suppressing effects after the body adjusts to the drug. On the contrary, it has been shown that phentermine did not lose effectiveness in a 36-week trial (PMID 11054601). However, the risk of drug addiction may be a significant reason in limiting phentermine for short-term use.

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